"X-Tinction Agenda" is a 1990 crossover comic book storyline published by Marvel Comics that ran through Uncanny X-Men and its spin-off titles, X-Factor and New Mutants. "X-Tinction Agenda" not only reunited the X-Men after a prolonged period in which the team had been scattered around the globe, but featured the combined might of the three mutant teams for the first time, in their fight against the mutant-exploiting Genoshan government.

Uncanny X-Men, originally published as The X-Men, is an American comic book series published by Marvel Comics since 1963, and is the longest-running series in the X-Men comics franchise. It features a team of superheroes called the X-Men, a group of mutants with superhuman abilities led and taught by Professor X.