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X-inactivation
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X-inactivation is a process by which one of the copies of the X chromosome is inactivated in therian female mammals. The inactive X chromosome is silenced by being packaged into a transcriptionally in
The coloration of tortoiseshell cats is a visible manifestation of X-inactivation. The black and orange alleles of a fur coloration gene reside on the X chromosome. For any given patch of fur, the inactivation of an X chromosome that carries one allele results in the fur color of the other, active allele.
The coloration of tortoiseshell cats is a visible manifestation of X-inactivation. The black and orange alleles of a fur coloration gene reside on the
Nucleus of a female cell. Top: Both X-chromosomes are detected, by FISH. Bottom: The same nucleus stained with a DNA stain (DAPI). The Barr body is in
Nucleus of a female cell. Top: Both X-chromosomes are detected, by FISH. Bottom: The same nucleus stained with a DNA stain (DAPI). The Barr body is indicated by the arrow, it identifies the inactive X (Xi).
The figure shows confocal microscopy images from a combined RNA-DNA FISH experiment for Xist in fibroblast cells from adult female mouse, demonstratin
The figure shows confocal microscopy images from a combined RNA-DNA FISH experiment for Xist in fibroblast cells from adult female mouse, demonstrating that Xist RNA is coating only one of the X-chromosomes. RNA FISH signals from Xist RNA are shown in red color, marking the inactive X-chromosome (Xi). DNA FISH signals from Xist loci are shown in yellow color, marking both active and inactive X-chromosomes (Xa, Xi). The nucleus (DAPI-stained) is shown in blue color. The figure is adapted from:.
Calico cat
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A calico cat is a domestic cat of any breed with a tricolor coat of black-based and red-based pigments with white. Outside of North American English, this coat pattern is called tricolor or tortoisesh
X-inactivation
…Skewed X-inactivation Calico cat Developmental disorders thought to be related to X-inactivation: Early infantile epileptic encephalopathy type 9 Frontonasal dysplasia…
A long-haired adult calico cat
A long-haired adult calico cat
Calico cat of blue (diluted) tortoiseshell and white
Calico cat of blue (diluted) tortoiseshell and white
Calico cat with predominantly black coloration
Calico cat with predominantly black coloration
Detail from Still life with Cat and fish by Jean Siméon Chardin, 1728
Detail from Still life with Cat and fish by Jean Siméon Chardin, 1728