The Manchu-led Qing dynasty of China ruled over Xinjiang from the late 1750s to 1912. In the history of Xinjiang, the Qing rule was established in the final phase of the Dzungar–Qing Wars when the Dzungar Khanate was conquered by the Qing dynasty, and lasted until the fall of the Qing dynasty in 1912. The post of General of Ili was established to govern the whole of Xinjiang and reported to the Lifan Yuan, a Qing government agency that oversaw the empire's frontier regions. Xinjiang was turned into a province in 1884.

The Qing dynasty, officially the Great Qing, was a Manchu-led imperial dynasty of China and the last imperial dynasty in Chinese history. The dynasty, proclaimed in Shenyang in 1636, seized control of Beijing in 1644, which is considered the start of the dynasty's rule. The dynasty lasted until 1912, when it was overthrown in the Xinhai Revolution. In Chinese historiography, the Qing dynasty was preceded by the Ming dynasty and succeeded by the Republic of China. The multi-ethnic Qing dynasty assembled the territorial base for modern China. It was the largest imperial dynasty in the history of China and in 1790 the fourth-largest empire in world history in terms of territorial size. With over 426 million citizens in 1907, it was the most populous country in the world at the time.