The Yamasees were a multiethnic confederation of Native Americans who lived in the coastal region of present-day northern coastal Georgia near the Savannah River and later in northeastern Florida. The Yamasees engaged in revolts and wars with other native groups and Europeans living in North America, specifically from Florida to North Carolina.

Guale was a historic Native American chiefdom of Mississippian culture peoples located along the coast of present-day Georgia and the Sea Islands. Spanish Florida established its Roman Catholic missionary system in the chiefdom in the late 16th century.