The Yana are a group of Native Americans indigenous to Northern California in the central Sierra Nevada, on the western side of the range. Their lands, prior to encroachment by white settlers, bordered the Pit and Feather rivers. They were nearly destroyed during the California genocide in the latter half of the 19th century. The Central and Southern Yana continue to live in California as members of Redding Rancheria.

The Pit River is a major river draining from northeastern California into the state's Central Valley. The Pit, the Klamath and the Columbia are the only three rivers in the U.S. that cross the Cascade Range.