The Yaquina River is a stream, 59 miles (95 km) long, on the Pacific coast of the U.S. state of Oregon. It drains an area of the Central Oregon Coast Range west of the Willamette Valley near Newport.

The Central Oregon Coast Range is the middle section of the Oregon Coast Range, in the Pacific Coast Ranges physiographic region, and located in the west-central portion of the state of Oregon, United States roughly between the Salmon River and the Umpqua River and the Willamette Valley and the Pacific Ocean. This approximately 90-mile (140 km) long mountain range contains mountains as high as 4,097 feet for Marys Peak. Portions of the range are inside the Siuslaw National Forest and three wilderness areas exist as well: Drift Creek Wilderness, Cummins Creek Wilderness and Rock Creek Wilderness.