Yedikule Fortress is a fortified historic structure located in the Yedikule neighbourhood of Fatih, in Istanbul, Turkey.

Yedikule is a neighbourhood in the municipality and district of Fatih, Istanbul Province, Turkey. Its population is 15,789 (2022). It is named after the seven-towered Yedikule Fortress, which surrounds the neighborhood. Urbanized in the 16th century, the neighborhood became a hub for industrial and agricultural activities. Yedikule has a local football team Yedikule GSK that played in the TFF Second League for a season.