Yesler Way is an east–west street in Seattle named for Henry Yesler, the founder of Seattle. East–west streets in Seattle south of Yesler Way are prefixed "South"; avenues are suffixed with "South" as they cross Yesler Way. The street originates at Alaskan Way on the downtown Seattle waterfront and runs east through Yesler Terrace, the Central District, and Leschi to just east of 32nd Avenue, where the arterial route switches to Lake Dell Avenue. A short residential segment of East Yesler Way, which turns into east of Broadway, exists to the west of Lake Washington Boulevard.

Seattle is a seaport city on the West Coast of the United States. It is the seat of King County, Washington. With a 2022 population of 749,256 it is the most populous city in both the state of Washington and the Pacific Northwest region of North America, and the 18th-most populous city in the United States. The Seattle metropolitan area's population is 4.02 million, making it the 15th-largest in the United States. Its growth rate of 21.1% between 2010 and 2020 made it one of the country's fastest-growing large cities.