The Yolla Bolly–Middle Eel Wilderness is a federally designated wilderness area in the Yolla Bolly Range of the southern Klamath Mountains and the Inner Northern California Coast Ranges, in Northern California.

The Klamath Mountains are a rugged and lightly-populated mountain range in northwestern California and southwestern Oregon in the western United States. As a mountain system within both the greater Pacific Coast Ranges and the California Coast Ranges, the Klamath Mountains have a varied geology, with substantial areas of serpentinite and marble, and a climate characterized by moderately cold winters with very heavy snowfall and warm, very dry summers with limited rainfall, especially in the south. As a consequence of the geology and soil types, the mountains harbor several endemic or near-endemic trees, forming one of the largest collections of conifers in the world. The mountains are also home to a diverse array of fish and animal species, including black bears, large cats, owls, eagles, and several species of Pacific salmon. Millions of acres in the mountains are managed by the United States Forest Service. The northernmost and largest sub-range of the Klamath Mountains are the Siskiyou Mountains.