The York, Newcastle and Berwick Railway (YN&BR) was an English railway company formed in 1847 by the amalgamation of the York and Newcastle Railway and the Newcastle and Berwick Railway. Both companies were part of the group of business interests controlled by George Hudson, the so-called Railway King. In collaboration with the York and North Midland Railway and other lines he controlled, he planned that the YN&BR would form the major part of a continuous railway between London and Edinburgh. At this stage the London terminal was Euston Square and the route was through Normanton. This was the genesis of the East Coast Main Line, but much remained to be done before the present-day route was formed, and the London terminus was altered to King's Cross.

George Hudson was an English railway financier and politician who, because he controlled a significant part of the railway network in the 1840s, became known as "The Railway King"—a title conferred on him by Sydney Smith in 1844.