The York River is a navigable estuary, approximately 34 miles (55 km) long, in eastern Virginia in the United States. It ranges in width from 1 mile (1.6 km) at its head to 2.5 miles (4.0 km) near its mouth on the west side of Chesapeake Bay. Its watershed drains an area of the coastal plain of Virginia north and east of Richmond.

Werowocomoco was a village that served as the headquarters of Chief Powhatan, a Virginia Algonquian political and spiritual leader when the English founded Jamestown in 1607. The name Werowocomoco comes from the Powhatan werowans (weroance), meaning "leader" in English; and komakah (-comoco), "settlement". The town was documented by English settlers in 1608 as located near the north bank of the York River in what is now Gloucester County. It was separated by that river and the narrow Virginia Peninsula from the English settlement of Jamestown, located on the James River.