You, Me and Dupree is a 2006 American romantic comedy film directed by Anthony Russo and Joe Russo and written by Mike LeSieur. It stars Owen Wilson, Kate Hudson, Matt Dillon, Seth Rogen, Amanda Detmer, Todd Stashwick, and Michael Douglas.

Anthony Russo and Joseph Russo, collectively known as the Russo brothers, are American directors, producers, and screenwriters. They direct most of their work together. They are best known for directing four films in the Marvel Cinematic Universe (MCU): Captain America: The Winter Soldier (2014), Captain America: Civil War (2016), Avengers: Infinity War (2018), and Avengers: Endgame (2019). Endgame grossed over $2.798 billion worldwide, briefly becoming the highest-grossing film of all time.