You Bet Your Life is an American comedy quiz series that has aired on both radio and television. The original version was hosted by Groucho Marx of the Marx Brothers, with announcer and assistant George Fenneman. The show debuted on ABC Radio on October 27, 1947, moved to CBS Radio debuting October 5, 1949, and went to NBC-TV and NBC Radio on October 4, 1950. Because of its simple format, it was possible to broadcast the show on both radio and television but not simultaneously. Many of the laughs on the television show were evoked by Groucho's facial reactions and other visual gimmicks; the two versions were slightly different. The last episode in a radio format aired on June 10, 1960. The series continued on television for another year, recording a season on September 22, 1960 with a new title, The Groucho Show.

The Marx Brothers were an American family comedy act that was successful in vaudeville, on Broadway, and in 14 motion pictures from 1905 to 1949. Five of the Marx Brothers' fourteen feature films were selected by the American Film Institute (AFI) as among the top 100 comedy films, with two of them, Duck Soup (1933) and A Night at the Opera (1935), in the top fifteen. They are widely considered by critics, scholars and fans to be among the greatest and most influential comedians of the 20th century. The brothers were included in AFI's 100 Years... 100 Stars list of the 25 greatest male stars of Classical Hollywood cinema, the only performers to be included collectively.