You Can't Go Home Again is a novel by Thomas Wolfe published posthumously in 1940, extracted by his editor, Edward Aswell, from the contents of his vast unpublished manuscript The October Fair. It is a sequel to The Web and the Rock, which, along with the collection The Hills Beyond, was extracted from the same manuscript.

Thomas Clayton Wolfe was an American writer. The Encyclopedia of Twentieth-Century Fiction states that "Wolfe was a major American novelist of the first half of the twentieth century, whose longterm reputation rests largely on the impact of his first novel, Look Homeward, Angel (1929), and on the short fiction that appeared during the last years of his life." Along with William Faulkner, he is considered one of the two most important authors of the Southern Renaissance within the American literary canon. He remains an important writer in modern American literature, as one of the first masters of autobiographical fiction, and is considered among North Carolina's most famous writers.