"You and Me" is a song by American alternative rock band Lifehouse. It is the first single released from their third studio album, Lifehouse (2005). The track was written by lead singer Jason Wade and American record producer Jude Cole. It was recorded and produced by John Alagía at his home studio in Easton, Maryland. The song was first released via digital download on January 28, 2005. It was then solicited to mainstream radio on March 15, 2005. An extended wedding version of the song was then released on July 26, 2005.

Lifehouse is an American rock band from Los Angeles, California comprising Jason Wade, Rick Woolstenhulme Jr., Bryce Soderberg, and Steve Stout. The band came to mainstream prominence with their 2000 single "Hanging by a Moment," which led their debut studio album, No Name Face (2000). The song peaked at number two on the Billboard Hot 100, won a Billboard Music Award for Hot 100 Single of the Year—having spent 20 weeks within the top ten and over a cumulative year on the chart—and was named the best-performing single of 2001 despite not reaching the top position, making it the fourth song in the chart's history to do so.