Ysgol Uwchradd Caergybi is a secondary school in Holyhead, Anglesey. It claims to be the first comprehensive school in England and Wales, opening in 1949 as Holyhead County School.

Holyhead is the largest town and a community in the county of Isle of Anglesey, Wales, with a population of 13,659 at the 2011 census.. Holyhead is on Holy Island, bounded by the Irish Sea to the north, and is separated from Anglesey island by the narrow Cymyran Strait and was originally connected to Anglesey via the Four Mile Bridge.