Zanesville is a city in and the county seat of Muskingum County, Ohio, United States. Located at the confluence of the Licking and Muskingum rivers, the city is approximately 52 miles (84 km) east of Columbus and had a population of 24,765 as of the 2020 census, down from 25,487 as of the 2010 census. Historically the state capital of Ohio from 1810 to 1812, Zanesville anchors the Zanesville micropolitan area and is part of the greater Columbus-Marion-Zanesville combined statistical area.

Muskingum County is a county located in the U.S. state of Ohio. As of the 2020 census, the population was 86,410. Its county seat is Zanesville. Nearly bisected by the Muskingum River, the county name is based on a Delaware American Indian word translated as "town by the river" or "elk's eye". Muskingum County comprises the Zanesville, OH Micropolitan Statistical Area, which is also included in the Columbus-Marion-Zanesville, OH Combined Statistical Area. The Zanesville Micropolitan Statistical Area is the second-largest statistical area within the Combined Statistical Area, after the Columbus Metropolitan Statistical Area.