The Zapotec civilization was an indigenous pre-Columbian civilization that flourished in the Valley of Oaxaca in Mesoamerica. Archaeological evidence shows that their culture originated at least 2,500 years ago. The Zapotec archaeological site at the ancient city of Monte Albán has monumental buildings, ball courts, magnificent tombs and grave goods, including finely worked gold jewelry. Monte Albán was one of the first major cities in Mesoamerica. It was the center of a Zapotec state that dominated much of the territory which today is known as the Mexican state of Oaxaca.

Ahuitzotl was the eighth Aztec ruler, the Huey Tlatoani of the city of Tenochtitlan, son of princess Atotoztli II. His name literally means "Water Thorny" and was also applied to the otter. It is also theorized that more likely, the animal called ahuitzotl is actually the water opossum, the hand symbolizing its prehensile tail, which otters notably lack.