The Zapotec civilization was an indigenous pre-Columbian civilization that flourished in the Valley of Oaxaca in Mesoamerica. Archaeological evidence shows that their culture originated at least 2,500 years ago. The Zapotec archaeological site at the ancient city of Monte Albán has monumental buildings, ball courts, magnificent tombs and grave goods, including finely worked gold jewelry. Monte Albán was one of the first major cities in Mesoamerica. It was the center of a Zapotec state that dominated much of the territory which today is known as the Mexican state of Oaxaca.

In the history of the Americas, the pre-Columbian era, also known as the pre-contact era, spans from the original peopling of the Americas in the Upper Paleolithic to European colonization, which began with Christopher Columbus's voyage of 1492. Usually, the era covers the history of Indigenous cultures until significant influence by Europeans. This may have occurred decades or even centuries after Columbus for certain cultures.