Zaynab bint Ali, was the eldest daughter of Fatima and Ali ibn Abi Talib. The former was a daughter of the Islamic prophet Muhammad, and the latter was his cousin. Ali is also recognized as the fourth Rashidun caliph and the first Shia imam. Zaynab is best known for her role in the aftermath of the Battle of Karbala, in which her brother Husayn and most of her male relatives were massacred by the forces of the Umayyad caliph Yazid ibn Mua'awiya. Women and children in Husayn's camp were taken captive after the battle and marched to Kufa and then the Umayyad capital Damascus, where Zaynab gave impassioned speeches, condemning Yazid and spreading the news of Karbala. She was later freed and died shortly afterward in 682, but her burial site is uncertain. The two shrines associated with Zaynab in Damascus and Cairo are destinations for Muslim pilgrimage. She is considered to be a symbol of sacrifice, strength, and piety in Islam, and a role model for Muslim women, typifying courage, leadership, and defiance against oppression.

Husayn ibn Ali was an Alid political and religious leader. The grandson of the Islamic prophet Muhammad and a son of Ali ibn Abi Talib and Muhammad's daughter Fatima, as well as a younger brother of Hasan ibn Ali, Husayn is regarded as the third Imam in Shia Islam after his brother, Hasan, and before his son, Ali al-Sajjad. Being the grandson of the prophet, he is the member of the ahl al-bayt. He is also considered to be a member of the Ahl al-Kisa, and a participant in the event of the mubahala. Muhammad described him and his brother, Hasan, as the leaders of the youth of Paradise.