Zestafoni or Zestaphoni is the administrative center of Zestafoni District in Western Georgia. Zestafoni is the center of an ancient, historical part of Georgia – Margveti, which is a part of Imereti province. Zestafoni is the center of Margveti's Eparchy of the Georgian Orthodox Church. Zestafoni is situated in the furthest east of the Colchis Plateau, and is built on both banks of the Qvirila River.

Zestafoni is a municipality of Georgia, in the region of Imereti. The municipality covers a total area of 423 square kilometres and as of 2014 it had a population total of 57,628 people. Its main town is Zestafoni which is an important industrial center, with a large ferro-alloy plant processing manganese ore from nearby Chiatura. The municipality is a notable wine-growing region.