Zhang Jue was a Chinese military general and rebel. He was the leader of the Yellow Turban Rebellion during the late Eastern Han dynasty of China. He was said to be a follower of Taoism and a sorcerer. His name is sometimes read as Zhang Jiao, since the Chinese character of Zhang's given name can be read as either "Jiao" or "Jue". "Jue" is the traditional or literary reading, while "Jiao" is the modern or colloquial one.

The Antonine Plague of AD 165 to 180, also known as the Plague of Galen, was a prolonged and destructive epidemic, which impacted the Roman Empire. It was possibly contracted and spread by soldiers who were returning from campaign in the Near East. Scholars generally believe the plague was smallpox, although measles has also been suggested, and recent genetic evidence strongly suggests that the most severe form of smallpox only arose in Europe much later. In AD 169 the plague may have claimed the life of the Roman emperor Lucius Verus, who was co-regnant with Marcus Aurelius. These two emperors had risen to the throne by virtue of being adopted by the previous emperor, Antoninus Pius, and as a result, their family name, Antoninus, has become associated with the pandemic.