Zofiówka Sanatorium is a defunct mental health facility in the town of Otwock in Poland, built at the beginning of the 20th century. In the Second Polish Republic, the sanatorium complex was expanded with more buildings and staff. Zofiówka initially had 95 beds, but this number had increased to 275 by 1935. The Jewish history of Zofiówka came to its end in the course of the Holocaust following the invasion of Poland by Nazi Germany.

Otwock is a city in the Masovian Voivodship in east-central Poland, some 23 kilometres (14 mi) southeast of Warsaw, with 44,635 inhabitants (2019). Otwock is a part of the Warsaw metropolitan area. It is situated on the right bank of Vistula River below the mouth of Świder River. Otwock is home to a unique architectural style called Świdermajer.