A global catastrophic risk or a doomsday scenario is a hypothetical event that could damage human well-being on a global scale, even endangering or destroying modern civilization. An event that could cause human extinction or permanently and drastically curtail humanity's existence or potential is known as an "existential risk."

Human extinction is the hypothetical end of the human species, either by population decline due to extraneous natural causes, such as an asteroid impact or large-scale volcanism, or via anthropogenic destruction (self-extinction), for example by sub-replacement fertility.