Merritt Island National Wildlife Refuge is a 140,000-acre (57,000 ha) U.S. National Wildlife Refuge (NWR) on the Atlantic coast of Florida's largest barrier island. NASA's Kennedy Space Center and visitor complex are also situated on the island and NASA can restrict access to the refuge based on its operational needs.

Titusville is a city in and the county seat of Brevard County, Florida, United States. As of the 2020 census, the population of the city was 48,789. Titusville is located along the Indian River, west of Merritt Island and the Kennedy Space Center, and south-southwest of the Canaveral National Seashore. It is a principal city of the Palm Bay–Melbourne–Titusville Metropolitan Statistical Area.