The Rogue River–Siskiyou National Forest is a United States National Forest in the U.S. states of Oregon and California. The formerly separate Rogue River and Siskiyou National Forests were administratively combined in 2004. Now, the Rogue River–Siskiyou National Forest ranges from the crest of the Cascade Range west into the Siskiyou Mountains, covering almost 1.8 million acres (7,300 km2). Forest headquarters are located in Medford, Oregon.

The Siskiyou Mountains are a coastal subrange of the Klamath Mountains, and located in northwestern California and southwestern Oregon in the United States. They extend in an arc for approximately 100 miles (160 km) from east of Crescent City, California, northeast along the north side of the Klamath River into Josephine and Jackson counties in Oregon. The mountain range forms a barrier between the watersheds of the Klamath River to the south and the Rogue River to the north. Accordingly, much of the range is within the Rogue River – Siskiyou and Klamath national forests, and the Pacific Crest Trail follows a portion of the crest of the Siskiyous.