Santa Ana is a district in the City of Manila, Philippines. It is located on the city's southeast, bordering the cities of Mandaluyong and Makati in the east, the city districts of Paco and Pandacan in the west, and Santa Mesa in the north. It is part of the 6th congressional district of Manila, with thirty-five barangays. Based on the 2020 national census, the Philippine Statistics Authority reports that the district has a population of 203,598.

Manila, officially the City of Manila, is the capital and second-most-populous city of the Philippines. Located on the eastern shore of Manila Bay on the island of Luzon, it is classified as a highly urbanized city. As of 2019, it is the world's most densely populated city proper. It was the first chartered city in the country, and was designated as such by the Philippine Commission Act No. 183 on July 31, 1901. It became autonomous with the passage of Republic Act No. 409, "The Revised Charter of the City of Manila", on June 18, 1949. Manila is considered to be part of the world's original set of global cities because its commercial networks were the first to extend across the Pacific Ocean and connect Asia with the Spanish Americas through the galleon trade; when this was accomplished, it was the first time an uninterrupted chain of trade routes circling the planet had been established.