U.S. Route 301 (US 301) in the state of Maryland is a major highway that runs 122.85 miles (197.71 km) from the Governor Harry W. Nice Memorial Bridge over the Potomac River into Virginia northeast to Delaware. It passes through three of Maryland's four main regions: Southern Maryland, the Baltimore-Washington Metropolitan Area, and the Eastern Shore. US 301 serves mainly as a bypass of Baltimore and Washington, D.C. from Virginia to Delaware.

Blue Star Memorial Highways are highways in the United States that are marked to pay tribute to the U.S. armed forces. The National Council of State Garden Clubs, now known as National Garden Clubs, Inc., started the program in 1945 after World War II. The blue star was used on service flags to denote a service member fighting in the war. The program has since been expanded to include Memorial Markers and Memorial By-ways. These markers are used in National Cemeteries, parks, veterans facilities, and gardens.