U.S. Route 46 (US 46) is an east–west U.S. Highway completely within the state of New Jersey, running for 75.34 mi (121.25 km), making it the shortest signed, non-spur U.S. Highway. The west end is at an interchange with Interstate 80 (I-80) and Route 94 in Columbia, Warren County, on the Delaware River. The east end is in the middle of the George Washington Bridge over the Hudson River in Fort Lee, Bergen County, while the route is concurrent with I-95 and US 1-9. Throughout much of its length, US 46 is closely paralleled by I-80. US 46 is a major local and suburban route, with some sections built to or near freeway standards and many other sections arterials with jughandles. The route runs through several communities in the northern part of New Jersey, including Hackettstown, Netcong, Dover, Parsippany-Troy Hills, Wayne, Clifton, Ridgefield Park, Palisades Park, and Fort Lee. It crosses over the Upper Passaic River at several points. The road has been ceremonially named the United Spanish–American War Veterans Memorial Highway.

Interstate 80 (I-80) is a major Interstate Highway in the United States, running from San Francisco, California, eastward to the New York metropolitan area. In New Jersey, I-80 runs for 68.35 miles (110.00 km) from the Delaware Water Gap Toll Bridge at the Pennsylvania state line to its eastern terminus at I-95 in Teaneck, Bergen County. I-95 continues from the end of I-80 to the George Washington Bridge for access to New York City. The highway runs parallel to U.S. Route 46 (US 46) through rural areas of Warren and Sussex counties before heading into more suburban surroundings in Morris County. As the road continues into Passaic and Bergen counties, it heads into more urban areas. The New Jersey Department of Transportation (NJDOT) identifies I-80 within the state as the Christopher Columbus Highway.