16 Avenue N is a major road in Calgary, Alberta, that forms a 26.5-kilometre (16.5 mi) segment of Highway 1 and connects Calgary to Banff and Medicine Hat. It is a four to six-lane principal arterial expressway at its extremities, but is an urban arterial road between the Bow River and Bowness Road, and also between Crowchild Trail and Deerfoot Trail. Due to Calgary's quadrant system, it is known as 16 Avenue NW west of Centre Street and 16 Avenue NE to the east.

The Trans-Canada Highway is a transcontinental federal–provincial highway system that travels through all ten provinces of Canada, from the Pacific Ocean on the west coast to the Atlantic Ocean on the east coast. The main route spans 7,476 km (4,645 mi) across the country, one of the longest routes of its type in the world. The highway system is recognizable by its distinctive white-on-green maple leaf route markers, although there are small variations in the markers in some provinces.