16th Street Mission station is a Bay Area Rapid Transit station located under Mission Street at 16th Street in the Mission District of San Francisco, California. Service at the station began, along with other stations between Montgomery Street Station and the Daly City station, on November 5, 1973. The station is served by the Red, Yellow, Green, and Blue lines.

Mission Street is a north-south arterial thoroughfare in Daly City and San Francisco, California that runs from Daly City's southern border to San Francisco's northeast waterfront. The street and San Francisco's Mission District through which it runs were named for the Spanish Mission Dolores, several blocks away from the modern route. Only the southern half is historically part of El Camino Real, which connected the missions. Part of Mission Street in Daly City is signed as part of State Route 82.