The 1859 United Kingdom general election returned Liberal Party to a majority of seats in the House of Commons. The Earl of Derby's Conservatives formed a minority government. but despite having made small overall gains in the election, Derby's government was defeated in a confidence vote by an alliance of Palmerston's Whigs together with Peelites, Radicals, and the Irish Brigade. Palmerston subsequently formed a new government from this alliance which is now considered to be the first Liberal Party administration.

The Peelites were a breakaway political faction of the British Conservative Party from 1846 to 1859. Initially led by Robert Peel, the former Prime Minister and Conservative Party leader in 1846, the Peelites supported free trade whilst the bulk of the Conservative Party remained protectionist. The Peelites later merged with the Whigs and Radicals to form the Liberal Party in 1859.