The 1880 United States presidential election in North Carolina took place on November 2, 1880, as part of the 1880 United States presidential election. Voters chose ten representatives, or electors to the Electoral College, who voted for president and vice president.

The 1880 United States presidential election was the 24th quadrennial presidential election, held on Tuesday, November 2, 1880, in which Republican nominee James A. Garfield defeated Winfield Scott Hancock of the Democratic Party. The voter turnout rate was one of the highest in the nation's history. Garfield was assassinated during his first year in office, and he was succeeded by his vice president, Chester A. Arthur.