The 1888 United States presidential election in Colorado took place on November 6, 1888, as part of the 1888 United States presidential election. Voters chose three representatives, or electors to the Electoral College, who voted for president and vice president.

The 1888 United States presidential election was the 26th quadrennial presidential election, held on Tuesday, November 6, 1888. Republican nominee Benjamin Harrison, a former U.S. senator from Indiana, defeated incumbent Democratic President Grover Cleveland of New York. It was the third of five U.S. presidential elections in which the winner did not win the national popular vote, which would not occur again until the 2000 US presidential election.