The 1906 College Football All-Southern Team consists of American football players selected to the College Football All-Southern Teams selected by various organizations for the 1906 Southern Intercollegiate Athletic Association football season. For some, the SIAA champion 1906 Vanderbilt Commodores football team made up the entire team. It would produce eight of the composite eleven. Owsley Manier was selected by Walter Camp third-team All-American. Vanderbilt won the SIAA championship.

The 1906 Vanderbilt Commodores football team represented Vanderbilt University during the 1906 Southern Intercollegiate Athletic Association football season. The team's head coach was Dan McGugin, who served his third season in that capacity. Members of the Southern Intercollegiate Athletic Association (SIAA), the Commodores played seven home games in Nashville, Tennessee at Curry Field, and finished the season with a record of 8–1 overall and 5–0 in SIAA.