The 1916 United States presidential election in Missouri was held on November 7, 1916 as part of the 1916 United States presidential election. Voters chose 18 representatives, or electors, to the Electoral College, who voted for president and vice president.

The 2020 United States presidential election in Missouri was held on Tuesday, November 3, 2020, as part of the 2020 United States presidential election in which all 50 states plus the District of Columbia participated. Missouri voters chose electors to represent them in the Electoral College via a popular vote, pitting the Republican Party's nominee, incumbent President Donald Trump of Florida, and running mate Vice President Mike Pence of Indiana against Democratic Party nominee, former Vice President Joe Biden of Delaware, and his running mate Senator Kamala Harris of California. Missouri has 10 electoral votes in the Electoral College.