The 1922 College Football All-Southern Team consists of college football players chosen by various organizations and writers for College Football All-Southern Teams for the 1922 Southern Conference football season. It was the first season of the Southern Conference.

The 1922 Vanderbilt Commodores football team represented Vanderbilt University during the 1922 Southern Conference football season. During the season, Dan McGugin's 18th as head coach, Vanderbilt compiled a record of 8–0–1 and outscored its opponents 177 to 16. The Commodores' defense was unrivaled in the South, leading the nation in giving up just 1.8 points per game, none of them at home. The season included a tie with Michigan at the dedication of the new Dudley Field; the first stadium in the South to be used exclusively for college football. The season was immediately dubbed one of the best in Vanderbilt and Southern football history.