The 1958 12-Hour Florida International Grand Prix of Endurance for the Amoco Trophy took place on 22 March, on the Sebring International Raceway,. It was the second round of the F.I.A. World Sports Car Championship, which was running to new regulations introduced at the beginning of the season. The most influential of these regulations changes would be the 3.0 litre engine size limit. This was seventh running of the 12-hour race.

The 12 Hours of Sebring is an annual motorsport endurance race for sports cars held at Sebring International Raceway, on the site of the former Hendricks Army Airfield World War II air base in Sebring, Florida, US. In the past, this race has been a round of the now defunct World Sportscar Championship, IMSA GT Championship and American Le Mans Series. In 2012, the race was the opening event of the FIA World Endurance Championship in a one off race before being returned back to the American Le Mans Series for 2013. Starting in 2014, the event became the second round of the WeatherTech SportsCar Championship.