The 1972 United States Senate elections were held on November 7, with the 33 seats of Class 2 contested in regular elections. They coincided with the landslide re-election of Republican President Richard Nixon. Despite Nixon's landslide victory, Democrats increased their majority by two seats. The Democrats picked up open seats in Kentucky and South Dakota, and defeated four incumbent senators: Gordon Allott of Colorado, J. Caleb Boggs of Delaware, Jack Miller of Iowa, and Margaret Chase Smith of Maine. The Republicans picked up open seats in New Mexico, North Carolina, and Oklahoma, and defeated one incumbent, William B. Spong Jr. of Virginia.

Jack Richard Miller was an American politician and jurist who served as a Republican United States Senator from Iowa for two terms from 1961 to 1973. He later served as a United States circuit judge of the United States Court of Appeals for the Federal Circuit.