The 1972 United States Senate election in Georgia took place on November 7, 1972, as one of that year's United States Senate elections. It was held concurrently with the 1972 presidential election. This seat had opened up following the death of Richard B. Russell in 1971. Shortly thereafter, Governor of Georgia Jimmy Carter appointed David H. Gambrell to fill Russell's vacant seat. The Democratic Party nominee was Sam Nunn, a conservative Democrat and member of the Georgia House of Representatives, and the Republican Party nominated Fletcher Thompson, the Representative from the Atlanta-area 5th congressional district of Georgia. In the primary, Nunn emerged victorious from a crowded field of Democratic candidates, including Gambrell and former Georgia Governor Ernest Vandiver. Despite President Richard Nixon defeating George McGovern in Georgia in the presidential election on the same day, Nunn defeated Thompson in both the special election 52% to 47% and general election 54% to 46%, both of which appeared on the same ballot.

The 1972 United States Senate elections were held on November 7, with the 33 seats of Class 2 contested in regular elections. They coincided with the landslide re-election of Republican President Richard Nixon. Despite Nixon's landslide victory, Democrats increased their majority by two seats. The Democrats picked up open seats in Kentucky and South Dakota, and defeated four incumbent senators: Gordon Allott of Colorado, J. Caleb Boggs of Delaware, Jack Miller of Iowa, and Margaret Chase Smith of Maine. The Republicans picked up open seats in New Mexico, North Carolina, and Oklahoma, and defeated one incumbent, William B. Spong Jr. of Virginia.