Under the Whyte notation for the classification of steam locomotives by wheel arrangement, 2-6-6-0 is a locomotive with one pair of unpowered leading wheels, followed by two sets of three pairs of powered driving wheels and no trailing wheels. The wheel arrangement was principally used on Mallet-type articulated locomotives. Some tank locomotive examples were also built, for which various suffixes to indicate the type of tank would be added to the wheel arrangement, for example 2-6-6-0T for an engine with side-tanks.

The South African Railways Class MC1 2-6-6-0 of 1914 was a steam locomotive.