Under the Whyte notation for the classification of steam locomotives by wheel arrangement, 2-6-6-0 is a locomotive with one pair of unpowered leading wheels, followed by two sets of three pairs of powered driving wheels and no trailing wheels. The wheel arrangement was principally used on Mallet-type articulated locomotives. Some tank locomotive examples were also built, for which various suffixes to indicate the type of tank would be added to the wheel arrangement, for example 2-6-6-0T for an engine with side-tanks.

The Whyte notation is a classification method for steam locomotives, and some internal combustion locomotives and electric locomotives, by wheel arrangement. It was devised by Frederick Methvan Whyte, and came into use in the early twentieth century following a December 1900 editorial in American Engineer and Railroad Journal.