The 2000 Indiana gubernatorial election was held on November 7, 2000. Incumbent Governor Frank O'Bannon, a Democrat, was re-elected over Republican David M. McIntosh with 57% of the vote. Libertarian Andrew Horning also ran and received 2% of the vote. O'Bannon's victory was the fourth consecutive election in which a Democrat was elected Governor of Indiana, the longest winning streak for that party in the state since 1856. As of 2023, this was the last time a Democrat was elected Governor of Indiana.

Frank Lewis O'Bannon was an American politician who served as the 47th governor of Indiana from 1997 until his death in 2003. He is the most recent U.S. Governor to have died in office.