The 2010 New York Mets season was the franchise's 49th season and their second at Citi Field. The team was attempting to rebound from the injury plagued 2009 season as they sought their first postseas

The 2010 San Diego Padres season was the 42nd season in franchise history. On August 25, the Padres had a 6+1⁄2-game lead over the second-place San Francisco Giants, but ended up missing the playoffs