Major floods along the Mississippi River in April and May 2011 were among the largest and most damaging recorded along the U.S. waterway in the past century, comparable in extent to the Great Mississippi Flood of 1927 and Great Flood of 1993. In April 2011, two large storm systems deposited record levels of rainfall on the Mississippi River drainage basin. When that additional water combined with the springtime snowmelt, the river and many of its tributaries began to swell to record levels by the beginning of May. Flooding occurred in Illinois, Missouri, Kentucky, Tennessee, Arkansas, Mississippi, and Louisiana.

The Great Mississippi Flood of 1927 was the most destructive river flood in the history of the United States, with 27,000 square miles (70,000 km2) inundated in depths of up to 30 feet (9 m) over the course of several months in early 1927. The period cost of the damage has been estimated to be between $246 million and $1 billion, which ranges from $4.2–$17.3 billion in 2023 dollars.