The 2016 United States presidential election in Mississippi was held on Tuesday, November 8, 2016, as part of the 2016 United States presidential election in which all 50 states plus the District of Columbia participated. Mississippi voters chose electors to represent them in the Electoral College via a popular vote, pitting the Republican Party's nominee, businessman Donald Trump, and running mate Indiana Governor Mike Pence against Democratic Party nominee, former Secretary of State Hillary Clinton, and her running mate Virginia Senator Tim Kaine. Mississippi has six electoral votes in the Electoral College.

Willie Wilson is an American businessman and perennial candidate from Chicago, Illinois. He unsuccessfully ran in the 2015, 2019, and 2023 Chicago mayoral elections, the 2016 United States presidential election, and for the United States Senate in 2020.