The 2020 United States presidential election in Missouri was held on Tuesday, November 3, 2020, as part of the 2020 United States presidential election in which all 50 states plus the District of Columbia participated. Missouri voters chose electors to represent them in the Electoral College via a popular vote, pitting the Republican Party's nominee, incumbent President Donald Trump of Florida, and running mate Vice President Mike Pence of Indiana against Democratic Party nominee, former Vice President Joe Biden of Delaware, and his running mate Senator Kamala Harris of California. Missouri has 10 electoral votes in the Electoral College.

The 2012 United States presidential election in Missouri took place on November 6, 2012, as part of the 2012 United States presidential election, in which all 50 states plus the District of Columbia participated. Missouri voters chose 10 electors to represent them in the Electoral College via a popular vote pitting incumbent Democratic President Barack Obama and his running mate, Vice President Joe Biden, against Republican challenger and former Massachusetts Governor Mitt Romney and his running mate, Congressman Paul Ryan.