The 2020 United States presidential election in Oklahoma was held on Tuesday, November 3, 2020, as part of the 2020 United States presidential election in which all 50 states plus the District of Columbia participated. Oklahoma voters chose electors to represent them in the Electoral College via a popular vote, pitting the Republican Party's nominee, incumbent President Donald Trump, and running mate Vice President Mike Pence against Democratic Party nominee, former Vice President Joe Biden, and his running mate California Senator Kamala Harris. Oklahoma has seven electoral votes in the Electoral College.

The Oklahoma Panhandle is a salient in the extreme northwestern region of the U.S. state of Oklahoma, consisting of Cimarron County, Texas County and Beaver County, from west to east. As with other salients in the United States, its name comes from the similarity of its shape to the handle of a pan. Its largest city is Guymon in Texas County. Black Mesa State Park, located in Cimarron County, is the highest point in the state. Other points of interest include Beaver Dunes Park, Optima Lake, and the Optima National Wildlife Refuge. Oklahoma Panhandle State University is ten miles away from Guymon.