The 2021–22 DFB-Pokal was the 79th season of the annual German football cup competition. Sixty-four teams participated in the competition, including all teams from the previous year's Bundesliga and 2. Bundesliga. The competition began on 6 August 2021 with the first of six rounds and ended on 21 May 2022 with the final at the Olympiastadion in Berlin, a nominally neutral venue, which has hosted the final since 1985. The DFB-Pokal is considered the second-most important club title in German football after the Bundesliga championship. The DFB-Pokal is run by the German Football Association (DFB).

The DFB-Pokal, also known as the German Cup in English, is a German knockout football cup competition held annually by the German Football Association (DFB). Sixty-four teams participate in the competition, including all clubs from the Bundesliga and the 2. Bundesliga along with the four best teams from the 3. Liga. It is considered the second-most important club title in German football after the Bundesliga championship. Taking place from August until May, the winner qualifies for the DFL-Supercup and the UEFA Europa League unless the winner already qualifies for the UEFA Champions League in the Bundesliga.