The 2024 United States Senate election in Missouri will be held on November 5, 2024, to elect a member of the United States Senate to represent the state of Missouri. Incumbent Republican Josh Hawley was first elected in 2018 with 51.4% of the vote defeating Democratic incumbent Claire McCaskill and is running for re-election to a second term in office. Primary elections will take place on August 6, 2024.

The 2018 United States Senate election in Missouri took place on November 6, 2018, to elect a member of the United States Senate to represent the State of Missouri, concurrently with other elections to the United States Senate, elections to the United States House of Representatives, and various state and local elections, including Missouri's quadrennial State Auditor election.