The 28th United States Congress was a meeting of the legislative branch of the United States federal government, consisting of the United States Senate and the United States House of Representatives. It met in Washington, D.C., from March 4, 1843, to March 4, 1845, during the third and fourth years of John Tyler's presidency. The apportionment of seats in this House of Representatives was based on the 1840 United States census. The Senate had a Whig majority, and the House had a Democratic majority.

John Tyler was an American politician who served as the tenth president of the United States from 1841 to 1845, after briefly holding office as the tenth vice president in 1841. He was elected vice president on the 1840 Whig ticket with President William Henry Harrison, succeeding to the presidency following Harrison's death 31 days after assuming office. Tyler was a stalwart supporter and advocate of states' rights, including regarding slavery, and he adopted nationalistic policies as president only when they did not infringe on the states' powers. His unexpected rise to the presidency posed a threat to the presidential ambitions of Henry Clay and other Whig politicians and left Tyler estranged from both of the nation's major political parties at the time.