A 4-4-4-4 steam locomotive, in the Whyte notation for describing locomotive wheel arrangements, has a four-wheel leading truck, two sets of four driving wheels, and a four-wheel trailing truck. While it would be possible to make an articulated locomotive of this arrangement, the only 4-4-4-4s ever built were duplex locomotives—with two sets of cylinders driving two sets of driven wheels in one rigid frame, essentially a 4-8-4 with divided drive.

The Whyte notation is a classification method for steam locomotives, and some internal combustion locomotives and electric locomotives, by wheel arrangement. It was devised by Frederick Methvan Whyte, and came into use in the early twentieth century following a December 1900 editorial in American Engineer and Railroad Journal.